A pandemic is probably a good moment to understand how vaccines are developed and how they work. This short and educational primer offers relevant background information on viruses and the immune system, and goes into much more detail on vaccines than other recent introductory books. How to Make a Vaccine is written by immunologist John Rhodes who brings to the table both his background in academic research on vaccines and his experience working for GlaxoSmithKline from 2001 to 2007. His narrative approach of choice is to tell the story of viruses, immunology, and vaccines through the history of scientific discovery.
Last year August, science writer Ed Yong put it very nicely: “you see, the immune system is very complicated“. Yet, understanding it is important to understanding how the COVID-19 pandemic might evolve, why we are faced with certain public health measures, and how we can hope to combat the pandemic with tests and vaccines. In this brief book, physics and chemistry professor Arup K. Chakraborty and immunologist Andrey S. Shaw offer a general introduction to how our immune system reacts to viruses, and how our medical inventions help out.
The best way to introduce this book is to quote the first sentence of the blurb: “Techno-Fix challenges the pervasive belief that technological innovation will save us from the dire consequences of the 300-year fossil-fuelled binge known as modern industrial civilization“. Stinging, provocative, and radical, Techno-Fix puts its fingers on many a sore spot with its searing critique.
Saying that the COVID-19 pandemic should not have happened will likely elicit one of two responses. Blaming China for initially trying to cover it up, or saying: “shit happens, this is speaking with the benefit of hindsight”. Appealing as these may sound, they are missing the bigger picture. The awful truth is that we have had this one coming for a long time.
When I reviewed the book Defending Biodiversity: Environmental Science and Ethics, one of the reasons that was discussed as to why we should protect nature was the possibility of undiscovered pharmaceutical drugs. Seasoned ethnobotanist Robert A. Voeks shows that this so-called jungle medicine narrative has a long history. Though partially true, it equally contains parts myth, sentimentality, and nostalgia. However, if you are expecting a sceptical critique of superstitious indigenous practices – I was initially wondering whether the book would – no, this book delivers something far more interesting. Without belittling traditional knowledge, Voeks instead exposes the flaws in our interpretation and delivers a nuanced and fascinating ethnobotanical history lesson to boot.
Antibiotics have been saving human lives since the drug Salvarsan was discovered in 1932. Penicillin went into mass-production in 1942. This is not a long time when you think about it, but a world without the protection offered by them already seems unimaginable. Not only have they offered protection from diseases such as tuberculosis, and stopped infections following injury or childbirth, they have also allowed us to develop surgical techniques requiring immune system suppression such as organ transplants. However, careless use of antibiotics has accelerated evolution of drug-resistant bacteria such that we are about to lose their protection.