CRISPR-Cas9

Book review – Life as We Made It: How 50,000 Years of Human Innovation Refined – and Redefined – Nature

7-minute read

Books can be like buses: nothing is written on a topic for ages and then two books appear in quick succession. The subtitle of Life as We Made It resembles that of the recently-reviewed Life Changing. Both books indeed cover the same topic: how humans have shaped the genetics and evolution of plants and animals around them. Despite some inevitable overlap, Beth Shapiro draws on two decades of her career as a geneticist to make Life as We Made It a beast all of its own. I found myself both thoroughly enjoying her fantastic science communication while disagreeing with her outlook.

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Book review – Life Changing: How Humans Are Altering Life on Earth

7-minute read

Ever since humans appeared on the scene, we have been altering life on Earth. Where once our actions could be considered part of nature’s fabric, our influence has become outsized and our options to exercise it have multiplied. Though the subtitle of Life Changing does not make it explicit, science writer Helen Pilcher focuses on our impact on the genetics and evolution of life around us. A book that stands out for its balanced tone, it managed to surprise me more than once, despite my familiarity with the topics considered.

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Book review – Some Assembly Required: Decoding Four Billion Years of Life, from Ancient Fossils to DNA

7-minute read

The history of life is punctuated by major transitions and inventions: fish that moved onto land, reptiles that turned into birds. But how did these happen? In Some Assembly Required, Professor of Organismal Biology and Anatomy Neil Shubin provides an up-to-date and utterly engrossing account of the latest thinking on the great transformations in evolution. And he has one clue for you: nothing ever begins when you think it does…

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Book review – End Times: A Brief Guide to the End of the World

6-minute read

If the end of the world is something that keeps you up at night you might want to skip this book. Some might snigger at the “rogue robots” in the book’s subtitle, but End Times is a serious look at so-called existential risks. Former foreign correspondent, reporter, and editor with TIME magazine Bryan Walsh takes an unflinching look at the various disasters that could wipe out humanity, the people whose jobs it is to seriously think through catastrophic threats, and how, if at all, we can prepare ourselves.

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Book review – The Mosquito: A Human History of Our Deadliest Predator

6-minute read

Ours is the latest generation to be engaged in a blood-soaked conflict that has lasted millennia. The quote “we have met the enemy, and he is us” might come to mind, but no. Rather, as E.O. Wilson once wrote: “It is the little things that run the world“. Historian Timothy C. Winegard here offers a sweeping history of major turning points in human history observed through the compound lens of the mosquito. With an estimated compound death toll of 52 billion an insect that is truly worthy of the title “destroyer of worlds”.

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Book review – Discovering Retroviruses: Beacons in the Biosphere

In the already unusual world of viruses, retroviruses stand out for being even more so. Called “retro” because they reverse the flow of genetic information from RNA to DNA, rather than the normal DNA to RNA, they have turned out to be ancient, omnipresent, and incredibly influential. They are also important as they cause diseases such as AIDS. With Discovering Retroviruses, Anna Marie Skalka delivers a book dedicated to this particular group that is as technical as it is fascinating.

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Book review – Hacking the Code of Life: How Gene Editing Will Rewrite Our Futures

Since being released on the world in 2012, the biotechnological tool CRISPR has been making headlines. Biologists used to rely on the relatively blunt tools of genetic modification, but this new tool is so precise and versatile that they now speak of gene editing instead. For people in a hurry, Nessa Carey here provides a primer on the powers and pitfalls of gene editing. Hacking the Code of Life is accessible to readers without much background in genetics, focusing more on the applications and the questions it raises than the nitty-gritty details of the tool itself.

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Book review – Kin: How We Came to Know Our Microbe Relatives

The problem with many history books is that they are written long after the facts, sometimes when the original protagonists are no longer alive. Historians or journalists often have no choice but to puzzle together the pieces of their story from eyewitness testimony or archival sources. Kin: How We Came to Know Our Microbe Relatives is a welcome exception to this rule. Written by emeritus microbiology professor John L. Ingraham, currently 94 years young, this book gives an intellectual history of the discipline of microbiology based on over seven decades of first-hand involvement and observation.

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Book review – Extended Heredity: A New Understanding of Inheritance and Evolution

In my recent review of She Has Her Mother’s Laugh: The Powers, Perversions, and Potential of Heredity, I mentioned how the concept of heredity has become ever fuzzier the more we have learnt about how traits can be passed to the next generation. We have come from a very gene-centric period in biology, but biologists Russell Bonduriansky and Troy Day are ready to shake up the field. Neither a Lamarckian redux nor an attempt to downplay the importance of genes, this book successfully argues that the time has come to take into account non-genetic forms of heredity. Along the way, they provide a very interesting history lesson on how we got here in the first place.

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Book review – Lamarck’s Revenge: How Epigenetics Is Revolutionizing Our Understanding of Evolution’s Past and Present

As one of several intellectuals who wrote about evolution before Darwin, time has not been kind to the French naturalist Jean-Baptiste Lamarck (1744-1829). Reviled during his lifetime by the influential Cuvier, after his death he became best remembered, and ultimately ridiculed, for the idea that characters acquired during an organism’s lifetime are passed on to its offspring. With the rise of the modern field of epigenetics, some of his ideas are making a comeback, albeit modified and adapted for the 21st Century. Palaeontologist and astrobiologist Peter Ward would even like to go so far as to restore some honour to his name and consider epigenetics a neo-Lamarckian process.

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