A pandemic is probably a good moment to understand how vaccines are developed and how they work. This short and educational primer offers relevant background information on viruses and the immune system, and goes into much more detail on vaccines than other recent introductory books. How to Make a Vaccine is written by immunologist John Rhodes who brings to the table both his background in academic research on vaccines and his experience working for GlaxoSmithKline from 2001 to 2007. His narrative approach of choice is to tell the story of viruses, immunology, and vaccines through the history of scientific discovery.
Last year August, science writer Ed Yong put it very nicely: “you see, the immune system is very complicated“. Yet, understanding it is important to understanding how the COVID-19 pandemic might evolve, why we are faced with certain public health measures, and how we can hope to combat the pandemic with tests and vaccines. In this brief book, physics and chemistry professor Arup K. Chakraborty and immunologist Andrey S. Shaw offer a general introduction to how our immune system reacts to viruses, and how our medical inventions help out.
Antibiotics have been saving human lives since the drug Salvarsan was discovered in 1932. Penicillin went into mass-production in 1942. This is not a long time when you think about it, but a world without the protection offered by them already seems unimaginable. Not only have they offered protection from diseases such as tuberculosis, and stopped infections following injury or childbirth, they have also allowed us to develop surgical techniques requiring immune system suppression such as organ transplants. However, careless use of antibiotics has accelerated evolution of drug-resistant bacteria such that we are about to lose their protection.