Most people will at least be mildly familiar with the story of how the structure of DNA was discovered. Francis Crick and James D. Watson are household names in this story as they went on to win a Nobel Prize. But can you name the third person to share it with them? Most people will also have heard of Rosalind Franklin, but as Gareth Williams shows, so many other people were relevant to this story. Watson and Crick only put the finishing cherry on the cake. Unravelling the Double Helix covers the preceding 85 years of breakthroughs, blind alleys, near-misses, and “beautifully executed bellyflops” by some of the greatest scientists of their time.
Since being released on the world in 2012, the biotechnological tool CRISPR has been making headlines. Biologists used to rely on the relatively blunt tools of genetic modification, but this new tool is so precise and versatile that they now speak of gene editing instead. For people in a hurry, Nessa Carey here provides a primer on the powers and pitfalls of gene editing. Hacking the Code of Life is accessible to readers without much background in genetics, focusing more on the applications and the questions it raises than the nitty-gritty details of the tool itself.
After the recently published Lamarck’s Revenge: How Epigenetics Is Revolutionizing Our Understanding of Evolution’s Past and Present left me little the wiser on how epigenetics actually works, I decided to track down a copy of Nessa Carey’s The Epigenetics Revolution. As one of two popular books published around the same time, it seemed like a good place to start. Peter Ward was right about one thing, this is indeed a landmark book, even if it is now a few years old.
As one of several intellectuals who wrote about evolution before Darwin, time has not been kind to the French naturalist Jean-Baptiste Lamarck (1744-1829). Reviled during his lifetime by the influential Cuvier, after his death he became best remembered, and ultimately ridiculed, for the idea that characters acquired during an organism’s lifetime are passed on to its offspring. With the rise of the modern field of epigenetics, some of his ideas are making a comeback, albeit modified and adapted for the 21st Century. Palaeontologist and astrobiologist Peter Ward would even like to go so far as to restore some honour to his name and consider epigenetics a neo-Lamarckian process.
After I read and reviewed Who We Are and How We Got Here: Ancient DNA and the New Science of the Human Past, I thought I knew about the changes to the story of human evolution based on studies of DNA. And given that Ancestors in Our Genome was published a few years before that book, I was curious what it could add to what I had been reading so far. As it turns out, a lot. As with my previous review, I should preface this one with the same warning that things are about to get complicated…
When I opened this book and read its sales pitch (I paraphrase: “What if I told you of a new fortune-telling device that can predict psychological traits – it’s called the DNA revolution!”) I raised my inquisitive but sceptical eyebrow somewhat. Did I just pick up another piece of pop-psychology pulp? Oh boy, was I wrong! Behavioural geneticist Robert Plomin has written an incredibly interesting book with Blueprint, explaining how rapid advances in DNA sequencing technology are opening vast new vistas on the genetics underlying psychology. And is it ever so different, and more complex, than what hyped-up newspaper headlines have tried to sell us so far.
Ask most biologists about the history of genetics and they will likely mention Watson and Crick’s 1953 discovery of the double helix structure of DNA or the work of the monk Gregor Mendel that showed a simple form of trait inheritance. Professor of History Theodore M. Porter contends that there is another, largely forgotten side to this story. Long before words such as genetics and genes had been coined, the fledgeling discipline of psychiatry was recording details of patients in mental asylums, collecting vast amounts of data on human heredity. Genetics in the Madhouse is a deep dive into the archives to reveal this little-known history.
If Charles Darwin were to walk into my office today and ask me: “So, what did I miss?” I think I would sit the good man down with a copy of She Has Her Mother’s Laugh, telling him: “Here, this should get you up to speed”. Darwin struggled to explain how traits were being inherited from generation to generation. As New York Times columnist Carl Zimmer shows in this wide-ranging book, the story of heredity has turned out to be both diverse and wonderful, but has also been misappropriated to prop up some horrible ideologies.
You may have missed it, but archaeology is undergoing a silent revolution. The story of our deep history used to be based on skeletal remains, linguistics, and the analysis of objects and tools our ancestors left behind, but since about three years archaeologists have a new tool in their arsenal. The analysis of DNA from old bones, or ancient DNA. David Reich has been at the forefront of developing this technique and argues that it is rewriting most of what we thought we knew about the last 350,000 years or so of human history. Brace yourself, things are about to get complicated…
After recently reading Doudna & Sternberg’s book A Crack in Creation, this book was the next one I wanted to read to learn more about CRISPR-Cas9, the new technique to edit genetic material that has been taking the world by storm. As it turns out, it was the right order to read the books in. If you have not heard of CRISPR before, I recommend you have a look at my review of Doudna’s book first.